PGC-1α Integrates Insulin Signaling, Mitochondrial Regulation, and Bioenergetic Function in Skeletal Muscle

The pathophysiology underlying mitochondrial dysfunction in insulin-resistant skeletal muscle is incompletely characterized. To further delineate this we investigated the interaction between insulin signaling, mitochondrial regulation, and function in C2C12 myotubes and in skeletal muscle. In myotub...

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Hlavní autoři: Pagel-Langenickel, Ines, Bao, Jianjun, Joseph, Joshua J., Schwartz, Daniel R., Mantell, Benjamin S., Xu, Xiuli, Raghavachari, Nalini, Sack, Michael N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Metabolism and Bioenergetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504883/
https://ncbi.nlm.nih.gov/pubmed/18579525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800842200
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