An allosteric model of calmodulin explains differential activation of PP2B and CaMKII

Calmodulin plays a vital role in mediating bidirectional synaptic plasticity by activating either calcium/calmodulin-dependent protein kinase II (CaMKII) or protein phosphatase 2B (PP2B) at different calcium concentrations. We propose an allosteric model for calmodulin activation, in which binding t...

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Bibliographic Details
Main Authors: Stefan, Melanie I., Edelstein, Stuart J., Le Novère, Nicolas
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504824/
https://ncbi.nlm.nih.gov/pubmed/18669651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804672105
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