Gene-Environment Interaction in the Onset of Eczema in Infancy: Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure

BACKGROUND: Loss-of-function variants in the gene encoding filaggrin (FLG) are major determinants of eczema. We hypothesized that weakening of the physical barrier in FLG-deficient individuals may potentiate the effect of environmental exposures. Therefore, we investigated whether there is an intera...

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Main Authors: Bisgaard, Hans, Simpson, Angela, Palmer, Colin N.A, Bønnelykke, Klaus, Mclean, Irwin, Mukhopadhyay, Somnath, Pipper, Christian B, Halkjaer, Liselotte B, Lipworth, Brian, Hankinson, Jenny, Woodcock, Ashley, Custovic, Adnan
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504043/
https://ncbi.nlm.nih.gov/pubmed/18578563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0050131
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