OPCML Is a Broad Tumor Suppressor for Multiple Carcinomas and Lymphomas with Frequently Epigenetic Inactivation

BACKGROUND: Identification of tumor suppressor genes (TSGs) silenced by CpG methylation uncovers the molecular mechanism of tumorigenesis and potential tumor biomarkers. Loss of heterozygosity at 11q25 is common in multiple tumors including nasopharyngeal carcinoma (NPC). OPCML, located at 11q25, is...

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Hlavní autoři: Cui, Yan, Ying, Ying, van Hasselt, Andrew, Ng, Ka Man, Yu, Jun, Zhang, Qian, Jin, Jie, Liu, Dingxie, Rhim, Johng S., Rha, Sun Young, Loyo, Myriam, Chan, Anthony T. C., Srivastava, Gopesh, Tsao, George S. W., Sellar, Grant C., Sung, Joseph J. Y., Sidransky, David, Tao, Qian
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2008
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2500176/
https://ncbi.nlm.nih.gov/pubmed/18714356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002990
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