Microtubule cross-linking triggers the directional motility of kinesin-5

Although assembly of the mitotic spindle is known to be a precisely controlled process, regulation of the key motor proteins involved remains poorly understood. In eukaryotes, homotetrameric kinesin-5 motors are required for bipolar spindle formation. Eg5, the vertebrate kinesin-5, has two modes of...

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Bibliographic Details
Main Authors: Kapitein, Lukas C., Kwok, Benjamin H., Weinger, Joshua S., Schmidt, Christoph F., Kapoor, Tarun M., Peterman, Erwin J.G.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2500128/
https://ncbi.nlm.nih.gov/pubmed/18678707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200801145
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