Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice

Agrin and its receptor MuSK are required for the formation of the postsynaptic apparatus at the neuromuscular junction (NMJ). In the current model the local deposition of agrin by the nerve and the resulting local activation of MuSK are responsible for creating and maintaining the postsynaptic appar...

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Bibliographic Details
Main Authors: Lin, Shuo, Maj, Marcin, Bezakova, Gabriela, Magyar, Josef P., Brenner, Hans Rudolf, Ruegg, Markus A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2497462/
https://ncbi.nlm.nih.gov/pubmed/18685098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801683105
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