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Muscle-wide secretion of a miniaturized form of neural agrin rescues focal neuromuscular innervation in agrin mutant mice

Agrin and its receptor MuSK are required for the formation of the postsynaptic apparatus at the neuromuscular junction (NMJ). In the current model the local deposition of agrin by the nerve and the resulting local activation of MuSK are responsible for creating and maintaining the postsynaptic appar...

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Détails bibliographiques
Auteurs principaux: Lin, Shuo, Maj, Marcin, Bezakova, Gabriela, Magyar, Josef P., Brenner, Hans Rudolf, Ruegg, Markus A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2497462/
https://ncbi.nlm.nih.gov/pubmed/18685098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801683105
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