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The Induction of Atherogenic Dyslipidemia In Poloxamer 407-treated Mice Is Not Mediated Through PPARα
The copolymer surfactant poloxamer 407 (P-407) has been used to induce a dose-controlled dyslipidemia in both mice and rats. Human macrophages cultured with P-407 exhibit a concentration-dependent reduction in cholesterol efflux to apolipoprotein A1 (apoA1) due to down-regulation of the ATP-binding...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2496925/ https://ncbi.nlm.nih.gov/pubmed/18498712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1211/jpp.60.6.0011 |
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