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Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
BACKGROUND: The 70 kDa ribosomal protein S6 kinase (RPS6KB1), located at 17q23, is amplified and overexpressed in 10–30% of primary breast cancers and breast cancer cell lines. p70S6K is a serine/threonine kinase regulated by PI3K/mTOR pathway, which plays a crucial role in control of cell cycle, gr...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2496917/ https://ncbi.nlm.nih.gov/pubmed/18652687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-9-348 |
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