Transient cardiac expression of constitutively active Gα(q) leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways
Cardiac hypertrophy and dilatation can result from stimulation of signal transduction pathways mediated by heterotrimeric G proteins, especially G(q), whose α subunit activates phospholipase Cβ (PLCβ). We now report that transient, modest expression of a hemagglutinin (HA) epitope-tagged, constituti...
Furkejuvvon:
| Publikašuvnnas: | Proc Natl Acad Sci U S A |
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| Váldodahkkit: | , , , , , |
| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
National Academy of Sciences
1998
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| Fáttát: | |
| Liŋkkat: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24952/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811897/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.23.13893 |
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