Transient cardiac expression of constitutively active Gα(q) leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

Cardiac hypertrophy and dilatation can result from stimulation of signal transduction pathways mediated by heterotrimeric G proteins, especially G(q), whose α subunit activates phospholipase Cβ (PLCβ). We now report that transient, modest expression of a hemagglutinin (HA) epitope-tagged, constituti...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Mende, U., Kagen, A., Cohen, A., Aramburu, J., Schoen, F. J., Neer, E. J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24952/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811897/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.23.13893
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