CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis

The migration of lymphocytes into the CNS during viral encephalitis is hindered by the blood–brain barrier (BBB) such that most infiltrating cells remain localized to perivascular spaces. This sequestration of leukocytes away from the parenchyma is believed to protect the CNS from immunopathologic i...

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Hlavní autoři: McCandless, Erin E., Zhang, Bo, Diamond, Michael S., Klein, Robyn S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2495012/
https://ncbi.nlm.nih.gov/pubmed/18678898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800898105
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