Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation

Impaired host defense post-bone marrow transplant (BMT) is related to overproduction of prostaglandin E(2) (PGE(2)) by alveolar macrophages (AMs). We show AMs post-BMT overproduce granulocyte-macrophage colony-stimulating factor (GM-CSF), whereas GM-CSF in lung homogenates is impaired both at baseli...

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Main Authors: Ballinger, Megan N., Hubbard, Leah L. N., McMillan, Tracy R., Toews, Galen B., Peters-Golden, Marc, Paine, Robert, Moore, Bethany B.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494794/
https://ncbi.nlm.nih.gov/pubmed/18456799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00309.2007
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