Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation

Two mechanisms are generally proposed to explain right precordial ST-segment elevation in Brugada syndrome: 1) right ventricular (RV) subepicardial action potential shortening and/or loss of dome causing transmural dispersion of repolarization; and 2) RV conduction delay. Here we report novel mechan...

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Hlavní autoři: Bébarová, Markéta, O'Hara, Tom, Geelen, Jan L. M. C., Jongbloed, Roselie J., Timmermans, Carl, Arens, Yvonne H., Rodriguez, Luz-Maria, Rudy, Yoram, Volders, Paul G. A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494753/
https://ncbi.nlm.nih.gov/pubmed/18456723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.91495.2007
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