The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population

OBJECTIVE— Hepatic glucokinase (GCK) is a key regulator of glucose storage and disposal in the liver, where its activity is competitively modulated, with respect to glucose, by binding to glucokinase regulatory protein (GCKR) in the presence of fructose 6-phosphate. Genome-wide association studies f...

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Bibliographic Details
Main Authors: Vaxillaire, Martine, Cavalcanti-Proença, Christine, Dechaume, Aurélie, Tichet, Jean, Marre, Michel, Balkau, Beverley, Froguel, Philippe
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2008
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494697/
https://ncbi.nlm.nih.gov/pubmed/18556336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1807
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