Angiotensin II Type 1 Receptor Signaling Contributes to Synaptophysin Degradation and Neuronal Dysfunction in the Diabetic Retina

OBJECTIVE—Pathogenic mechanisms underlying diabetes-induced retinal dysfunction are not fully understood. The aim of the present study was to show the relationship of the renin-angiotensin system (RAS) with the synaptic vesicle protein synaptophysin and neuronal activity in the diabetic retina. RESE...

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Main Authors: Kurihara, Toshihide, Ozawa, Yoko, Nagai, Norihiro, Shinoda, Kei, Noda, Kousuke, Imamura, Yutaka, Tsubota, Kazuo, Okano, Hideyuki, Oike, Yuichi, Ishida, Susumu
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2008
Teme:
Complications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494692/
https://ncbi.nlm.nih.gov/pubmed/18487452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1281
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