siRNA-Mediated Reduction of Inhibitor of Nuclear Factor-κB Kinase Prevents Tumor Necrosis Factor-α–Induced Insulin Resistance in Human Skeletal Muscle

OBJECTIVE—Proinflammatory cytokines contribute to systemic low-grade inflammation and insulin resistance. Tumor necrosis factor (TNF)-α impedes insulin signaling in insulin target tissues. We determined the role of inhibitor of nuclear factor-κB kinase (IKK)β in TNF-α–induced impairments in insulin...

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Detalhes bibliográficos
Main Authors: Austin, Reginald L., Rune, Anna, Bouzakri, Karim, Zierath, Juleen R., Krook, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2008
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494681/
https://ncbi.nlm.nih.gov/pubmed/18443205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-0763
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