Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin–Conditioned Dendritic Cells Induce Regulatory T-Cell Differentiation and Protection of NOD Mice Against Diabetes

OBJECTIVE—Autoimmune diabetes in the nonobese diabetic (NOD) mouse model results from a breakdown of T-cell tolerance caused by impaired tolerogenic dendritic cell development and regulatory T-cell (Treg) differentiation. Re-establishment of the Treg pool has been shown to confer T-cell tolerance an...

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Detalhes bibliográficos
Main Authors: Besin, Gilles, Gaudreau, Simon, Ménard, Michaël, Guindi, Chantal, Dupuis, Gilles, Amrani, Abdelaziz
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2008
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494678/
https://ncbi.nlm.nih.gov/pubmed/18477807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0171
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