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High Loading Efficiency and Tunable Release of Plasmid DNA Encapsulated in Submicron Particles Fabricated from PLGA Conjugated with Poly-L-lysine
Poly(lactic-co-glycolic acid) (PLGA) particles have been widely explored as vehicles for delivery of plasmid DNA to mammalian cells both in vitro and in vivo. Achieving high incorporation efficiencies and control over release kinetics are significant challenges in encapsulating hydrophilic molecules...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2494593/ https://ncbi.nlm.nih.gov/pubmed/18511145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2008.04.002 |
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