Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid

BACKGROUND: The clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of the utility of CRISPR–Cas9 for in vivo gene editing, a principal problem in implementing this new process is delivery of h...

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Detalhes bibliográficos
Publicado no:J Nanobiotechnology
Main Authors: Jo, Ami, Ringel-Scaia, Veronica M., McDaniel, Dylan K., Thomas, Cassidy A., Zhang, Rui, Riffle, Judy S., Allen, Irving C., Davis, Richey M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970287/
https://ncbi.nlm.nih.gov/pubmed/31959180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12951-019-0564-1
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