Costimulation with angiotensin II and interleukin 6 augments angiotensinogen expression in cultured human renal proximal tubular cells

Augmented intrarenal ANG II stimulates IL-6, which contributes to renal injury. The expression of intrarenal angiotensinogen (AGT) is enhanced by increased intrarenal ANG II in human renin/human AGT double transgenic mice. ANG II also augments AGT expression in hepatocytes and cardiac myocytes. Howe...

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Autori principali: Satou, Ryousuke, Gonzalez-Villalobos, Romer A., Miyata, Kayoko, Ohashi, Naro, Katsurada, Akemi, Navar, L. Gabriel, Kobori, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2008
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494515/
https://ncbi.nlm.nih.gov/pubmed/18463317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00047.2008
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