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Nephrin binds to the COOH terminus of a large-conductance Ca(2+)-activated K(+) channel isoform and regulates its expression on the cell surface

We carried out a yeast two-hybrid screen to identify proteins that interact with large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels encoded by the Slo1 gene. Nephrin, an essential adhesion and scaffolding molecule expressed in podocytes, emerged in this screen. The Slo1-nephrin interaction wa...

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Detalhes bibliográficos
Main Authors: Kim, Eun Young, Choi, Kyoung-Jae, Dryer, Stuart E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494500/
https://ncbi.nlm.nih.gov/pubmed/18480178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00140.2008
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