Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle

Previous work suggested that altered Ca(2+) homeostasis might contribute to dysfunction of nebulin-free muscle, as gene expression analysis revealed that the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA)-inhibitor sarcolipin (SLN) is up-regulated >70-fold in nebulin knockout mice, and here w...

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Main Authors: Ottenheijm, Coen A. C., Fong, Chi, Vangheluwe, Peter, Wuytack, Frank, Babu, Gopal J., Periasamy, Muthu, Witt, Christian C., Labeit, Siegfried, Granzier, Henk
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2008
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493448/
https://ncbi.nlm.nih.gov/pubmed/18434434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-104372
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