Učitavanje...
Mdm2 Promotes Genetic Instability and Transformation Independent of p53
Mdm2, a regulator of the tumor suppressor p53, is frequently overexpressed in human malignancies. Mdm2 also has unresolved, p53-independent functions that contribute to tumorigenesis. Here, we show that increased Mdm2 expression induced chromosome/chromatid breaks and delayed DNA double-strand break...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology (ASM)
2008
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2493369/ https://ncbi.nlm.nih.gov/pubmed/18541670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01584-07 |
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