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Reactive-Site Cleavage Residues Confer Target Specificity to Baculovirus P49, a Dimeric Member of the P35 Family of Caspase Inhibitors

Baculovirus proteins P49 and P35 are potent suppressors of apoptosis in diverse organisms. Although related, P49 and P35 inhibit initiator and effector caspases, respectively, during infection of permissive insect cells. The molecular basis of this novel caspase specificity is unknown. To advance st...

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Sonraí Bibleagrafaíochta
Main Authors: Guy, Michael P., Friesen, Paul D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493353/
https://ncbi.nlm.nih.gov/pubmed/18508888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00231-08
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