Induction of Broad CD4(+) and CD8(+) T-Cell Responses and Cross- Neutralizing Antibodies against Hepatitis C Virus by Vaccination with Th1-Adjuvanted Polypeptides Followed by Defective Alphaviral Particles Expressing Envelope Glycoproteins gpE1 and gpE2 and Nonstructural Proteins 3, 4, and 5

Broad, multispecific CD4(+) and CD8(+) T-cell responses to the hepatitis C virus (HCV), as well as virus-cross-neutralizing antibodies, are associated with recovery from acute infection and may also be associated in chronic HCV patients with a favorable response to antiviral treatment. In order to r...

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Bibliographische Detailangaben
Hauptverfasser: Lin, Yinling, Kwon, Taewoo, Polo, John, Zhu, Yi-Fei, Coates, Stephen, Crawford, Kevin, Dong, Christine, Wininger, Mark, Hall, John, Selby, Mark, Coit, Doris, Medina-Selby, Angelica, McCoin, Colin, Ng, Philip, Drane, Debbie, Chien, David, Han, Jang, Vajdy, Michael, Houghton, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493334/
https://ncbi.nlm.nih.gov/pubmed/18508900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02743-07
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