Intraluminal proteolytic activation plays an important role in replication of type 1 reovirus in the intestines of neonatal mice.

Oral inoculation of suckling mice with reovirus serotype 1 (strain Lang) results in the conversion of intact virions to intermediate subviral particles (ISVPs) in the intestinal lumen. Digestion of virus in vitro with chymotrypsin or trypsin reveals two distinct forms of ISVPs, while the predominant...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Bass, D M, Bodkin, D, Dambrauskas, R, Trier, J S, Fields, B N, Wolf, J L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC249324/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2157065/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.4.1830-1833.1990
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