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The Oligomerization Domain of C4-Binding Protein (C4bp) Acts as an Adjuvant, and the Fusion Protein Comprised of the 19-Kilodalton Merozoite Surface Protein 1 Fused with the Murine C4bp Domain Protects Mice against Malaria
Highly purified protein antigens are usually poor immunogens; in practice, adjuvants are needed to obtain satisfactory immune responses. Plasmodium yoelii 19-kDa merozoite surface protein 1 (MSP1(19)) is a weak antigen, but mice vaccinated with this antigen in strong adjuvants can survive an otherwi...
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Главные авторы: | , , , , |
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Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
American Society for Microbiology (ASM)
2008
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2493234/ https://ncbi.nlm.nih.gov/pubmed/18474650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01369-07 |
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