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The Oligomerization Domain of C4-Binding Protein (C4bp) Acts as an Adjuvant, and the Fusion Protein Comprised of the 19-Kilodalton Merozoite Surface Protein 1 Fused with the Murine C4bp Domain Protects Mice against Malaria

Highly purified protein antigens are usually poor immunogens; in practice, adjuvants are needed to obtain satisfactory immune responses. Plasmodium yoelii 19-kDa merozoite surface protein 1 (MSP1(19)) is a weak antigen, but mice vaccinated with this antigen in strong adjuvants can survive an otherwi...

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Библиографические подробности
Главные авторы: Ogun, Solabomi A., Dumon-Seignovert, Laurence, Marchand, Jean-Baptiste, Holder, Anthony A., Hill, Fergal
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493234/
https://ncbi.nlm.nih.gov/pubmed/18474650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01369-07
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