Malaria Vaccine-Related Benefits of a Single Protein Comprising Plasmodium falciparum Apical Membrane Antigen 1 Domains I and II Fused to a Modified Form of the 19-Kilodalton C-Terminal Fragment of Merozoite Surface Protein 1

We show that the smallest module of Plasmodium falciparum AMA1 (PfAMA1) that can be expressed in the yeast Pichia pastoris while retaining the capacity to induce high levels of parasite-inhibitory antibodies comprises domains I and II. Based on this, two fusion proteins, differing in the order of th...

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Hlavní autoři: Faber, Bart W., Remarque, Edmond J., Morgan, William D., Kocken, Clemens H. M., Holder, Anthony A., Thomas, Alan W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2007
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168333/
https://ncbi.nlm.nih.gov/pubmed/17938224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01804-06
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