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Identification of Mutations Related to Streptomycin Resistance in Clinical Isolates of Mycobacterium tuberculosis and Possible Involvement of Efflux Mechanism

The MIC for streptomycin in the presence of efflux pump (EP) inhibitors and the sequencing of rpsL, rrs, and gidB genes provided evidence for the possible participation of EP in low-level streptomycin (STR) resistance of some isolates without mutations. Mutation in the gidB gene and an EP could act...

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Autori principali: Spies, Fernanda S., Almeida da Silva, Pedro E., Ribeiro, Marta O., Rossetti, Maria Lucia, Zaha, Arnaldo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493096/
https://ncbi.nlm.nih.gov/pubmed/18541729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01570-07
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