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TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines

We have previously identified a cellular protein kinase activity termed TAK that specifically associates with the HIV types 1 and 2 Tat proteins. TAK hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II in vitro in a manner believed to activate transcription [He...

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Autori principali: Yang, Xinzhen, Gold, Moses O., Tang, Derek Ng, Lewis, Dorothy E., Aguilar-Cordova, Estuardo, Rice, Andrew P., Herrmann, Christine H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences of the USA 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC24930/
https://ncbi.nlm.nih.gov/pubmed/9356449
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