The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects

AIMS: The authors determined whether intravenous atropine can prevent or counteract the negative chronotropic effect of the immunomodulator fingolimod. METHODS: In this randomized, placebo-controlled, two-period, crossover study, 12 healthy subjects received 5 mg fingolimod orally concurrently with...

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Bibliographische Detailangaben
Hauptverfasser: Kovarik, John M, Slade, Alan, Riviere, Gilles-Jacques, Neddermann, Daniel, Maton, Steve, Hunt, Thomas L, Schmouder, Robert L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2008
Schlagworte:
Pharmacodynamics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492924/
https://ncbi.nlm.nih.gov/pubmed/18507656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03199.x
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