Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling

Cellular origins and genetic factors governing the genesis and maintenance of glioblastomas (GBM) are not well understood. Here, we report a pathogenetic role of the developmental regulator Id4 (inhibitor of differentiation 4) in GBM. In primary murine Ink4a/Arf(−/−) astrocytes, and human glioma cel...

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Detalhes bibliográficos
Main Authors: Jeon, Hye-Min, Jin, Xun, Lee, Joong-Seob, Oh, Se-Yeong, Sohn, Young-Woo, Park, Hyo-Jung, Joo, Kyeung Min, Park, Woong-Yang, Nam, Do-Hyun, DePinho, Ronald A., Chin, Lynda, Kim, Hyunggee
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492750/
https://ncbi.nlm.nih.gov/pubmed/18676808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1668708
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