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Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts
As an increasing number of non-cardiac drugs have been reported to cause QT interval prolongation and torsades de pointes (TdP), we extensively studied the utility of atrioventricular (AV) block animals as a model to predict their torsadogenic action in human. The present review highlights such in v...
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| Formato: | Artigo |
| Idioma: | Inglês |
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Nature Publishing Group
2008
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2492090/ https://ncbi.nlm.nih.gov/pubmed/18552873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.240 |
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