MGB probe assay for rapid detection of mtDNA11778 mutation in the Chinese LHON patients by real-time PCR

Objective: Leber’s hereditary optic neuropathy (LHON) is a maternally inherited degeneration of the optic nerve caused by point mutations of mitochondrial DNA (mtDNA). Many unsolved questions regarding the penetrance and pathophysiological mechanism of LHON demand efficient and reliable mutation tes...

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Detalhes bibliográficos
Main Authors: Wang, Jian-yong, Gu, Yang-shun, Wang, Jing, Tong, Yi, Wang, Ying, Shao, Jun-bing, Qi, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Zhejiang University Press 2008
Assuntos:
Biomedicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491690/
https://ncbi.nlm.nih.gov/pubmed/18763310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1631/jzus.B0820058
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