Neutralization-resistant variants of a neurotropic coronavirus are generated by deletions within the amino-terminal half of the spike glycoprotein.

Neuroattenuated variants of mouse hepatitis virus type 4 (MHV-4) selected for resistance to neutralizing monoclonal antibodies (R.G. Dalziel, P.W. Lampert, P. J. Talbot, and M. J. Buchmeier, J. Virol. 59:463-471, 1986) were found to harbor large deletions in both mRNA 3 and its protein product, the...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Gallagher, T M, Parker, S E, Buchmeier, M J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC249167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1688627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.2.731-741.1990
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