Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy

BCKGROUND: A number of studies have investigated whether the activity levels of enzymes involved in 5-fluorouracil (5-FU) metabolism are prognostic factors for survival in patients with colorectal carcinoma. Most reports have examined thymidylate synthetase (TS) and dihydropyrimidine dehydrogenase (...

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Autori principali: Ishikawa, Masashi, Miyauchi, Takayuki, Kashiwagi, Yutaka
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491633/
https://ncbi.nlm.nih.gov/pubmed/18597678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-188
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