IL-33 exacerbates antigen-induced arthritis by activating mast cells

IL-33, a cytokine of the IL-1 family, is closely associated with type II T cell responses. Here, we report an unexpected proinflammatory role of IL-33 in inflammatory arthritis. IL-33 was expressed in synovial fibroblasts from patients with rheumatoid arthritis (RA). Expression was markedly elevated...

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Bibliographische Detailangaben
Hauptverfasser: Xu, Damo, Jiang, Hui-Rong, Kewin, Peter, Li, Yubin, Mu, Rong, Fraser, Alasdair R., Pitman, Nick, Kurowska-Stolarska, Mariola, McKenzie, Andrew N. J., McInnes, Iain B., Liew, Foo Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491487/
https://ncbi.nlm.nih.gov/pubmed/18667700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801898105
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