Hepatic CB(1) receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

Diet-induced obesity is associated with fatty liver, insulin resistance, leptin resistance, and changes in plasma lipid profile. Endocannabinoids have been implicated in the development of these associated phenotypes, because mice deficient for the cannabinoid receptor CB(1) (CB1(–/–)) do not displa...

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Main Authors: Osei-Hyiaman, Douglas, Liu, Jie, Zhou, Liang, Godlewski, Grzegorz, Harvey-White, Judith, Jeong, Won-il, Bátkai, Sándor, Marsicano, Giovanni, Lutz, Beat, Buettner, Christoph, Kunos, George
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491458/
https://ncbi.nlm.nih.gov/pubmed/18677409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34827
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