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Methylation of Polycomb target genes in intestinal cancer is mediated by inflammation

Epigenetic changes are strongly associated with cancer development. DNA hypermethylation is associated with gene silencing and is often observed in CpG islands. Recently it was suggested that aberrant CpG island methylation in tumors is directed by Polycomb proteins. However, specific mechanisms res...

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Detalhes bibliográficos
Main Authors: Hahn, Maria A., Hahn, Torsten, Lee, Dong-Hyun, Esworthy, R. Steven, Kim, Byung-wook, Riggs, Arthur D., Chu, Fong-Fong, Pfeifer, Gerd P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491345/
https://ncbi.nlm.nih.gov/pubmed/19074896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1957
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