A Val-25-to-Ile substitution in the envelope precursor polyprotein, gPr80env, is responsible for the temperature sensitivity, inefficient processing of gPr80env, and neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.

ts1 is a neurovirulent spontaneous temperature-sensitive mutant of Moloney murine leukemia virus TB which causes hindlimb paralysis in mice. Previously, it had been shown that the temperature-sensitive defect resided in the env gene. At the restrictive temperature, the envelope precursor polyprotein...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Szurek, P F, Yuen, P H, Ball, J K, Wong, P K
Format: Artigo
Langue:Inglês
Publié: 1990
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC249133/
https://ncbi.nlm.nih.gov/pubmed/2296075
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires