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Increased accumulation of chloroquine and desethylchloroquine in homozygous sickle cells

The effect of haemoglobin genotype on the level of chloroquine in the erythrocytes of homozygous sickle-cell (SS), normal (AA), and heterozygous (AS) subjects was investigated in vivo and in vitro. Two hours after a single oral dose of chloroquine its level in plasma was consistently lower in SS tha...

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主要作者: Orjih, A. U.
格式: Artigo
語言:Inglês
出版: 1987
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490867/
https://ncbi.nlm.nih.gov/pubmed/3495366
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