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Structural Determinants Underlying the Temperature-sensitive Nature of a Gα Mutant in Asymmetric Cell Division of Caenorhabditis elegans

Heterotrimeric G-proteins are integral to a conserved regulatory module that influences metazoan asymmetric cell division (ACD). In the Caenorhabditis elegans zygote, GOA-1 (Gα(o)) and GPA-16 (Gα(i)) are involved in generating forces that pull on astral microtubules and position the spindle asymmetr...

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Autores principales: Johnston, Christopher A., Afshar, Katayoun, Snyder, Jason T., Tall, Gregory G., Gönczy, Pierre, Siderovski, David P., Willard, Francis S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490787/
https://ncbi.nlm.nih.gov/pubmed/18519563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803023200
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