p73α isoforms drive opposite transcriptional and post-transcriptional regulation of MYCN expression in neuroblastoma cells

MYCN activation, mainly by gene amplification, is one of the most frequent molecular events in neuroblastoma (NB) oncogenesis, and is associated with increased malignancy and decreased neuronal differentiation propensity. The frequency of concomitant loss of heterozygosity at the 1p36.3 locus, which...

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Bibliographic Details
Main Authors: Horvilleur, Emilie, Bauer, Matthieu, Goldschneider, David, Mergui, Xénia, de La Motte, Alix, Bénard, Jean, Douc-Rasy, Sétha, Cappellen, David
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490757/
https://ncbi.nlm.nih.gov/pubmed/18583365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn394
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