p73α isoforms drive opposite transcriptional and post-transcriptional regulation of MYCN expression in neuroblastoma cells

MYCN activation, mainly by gene amplification, is one of the most frequent molecular events in neuroblastoma (NB) oncogenesis, and is associated with increased malignancy and decreased neuronal differentiation propensity. The frequency of concomitant loss of heterozygosity at the 1p36.3 locus, which...

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Main Authors: Horvilleur, Emilie, Bauer, Matthieu, Goldschneider, David, Mergui, Xénia, de La Motte, Alix, Bénard, Jean, Douc-Rasy, Sétha, Cappellen, David
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2008
Assuntos:
Molecular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490757/
https://ncbi.nlm.nih.gov/pubmed/18583365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn394
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