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Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells

In the search of facile and efficient methods for cellular delivery of peptide nucleic acids (PNA), we have synthesized PNAs conjugated to oligophosphonates via phosphonate glutamine and bis-phosphonate lysine amino acid derivatives thereby introducing up to twelve phosphonate moieties into a PNA ol...

詳細記述

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書誌詳細
主要な著者: Shiraishi, Takehiko, Hamzavi, Ramin, Nielsen, Peter E.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490735/
https://ncbi.nlm.nih.gov/pubmed/18596083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn401
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