Structural analysis of urate oxidase in complex with its natural substrate inhibited by cyanide: Mechanistic implications

BACKGROUND: Urate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid and gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide, in the absence of cofactor or particular metal cation. The functional enzyme is a homo-tetramer with four active sites located at dimeric inter...

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Hauptverfasser: Gabison, Laure, Prangé, Thierry, Colloc'h, Nathalie, El Hajji, Mohamed, Castro, Bertrand, Chiadmi, Mohamed
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490695/
https://ncbi.nlm.nih.gov/pubmed/18638417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-8-32
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