The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture.

Eitemau Tebyg

• Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.
  gan: Sedman, S A, et al.
  Cyhoeddwyd: (1992)
• HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.
  gan: Hawley-Nelson, P, et al.
  Cyhoeddwyd: (1989)
• Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes.
  gan: Hubbert, N L, et al.
  Cyhoeddwyd: (1992)
• trans activation by the full-length E2 proteins of human papillomavirus type 16 and bovine papillomavirus type 1 in vitro and in vivo: cooperation with activation domains of cellular transcription factors.
  gan: Ushikai, M, et al.
  Cyhoeddwyd: (1994)
• Characterization of the human papillomavirus E2 protein: evidence of trans-activation and trans-repression in cervical keratinocytes.
  gan: Bouvard, V, et al.
  Cyhoeddwyd: (1994)