Recombinant CD4-selected human immunodeficiency virus type 1 variants with reduced gp120 affinity for CD4 and increased cell fusion capacity.

Variants of molecularly cloned human immunodeficiency virus type 1 (HIV-1) were analyzed following selection for the ability to replicate after exposure to soluble, recombinant CD4 protein (rCD4). Two variants, 4/1 and 16/2, show 8-fold and 16-fold reduced sensitivity to rCD4 neutralization yet rema...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	McKeating, J, Balfe, P, Clapham, P, Weiss, R A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248935/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1870202/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.9.4777-4785.1991
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