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The Leber Congenital Amaurosis Protein AIPL1 Functions as Part of a Chaperone Heterocomplex

PURPOSE: AIPL1 mutations cause the severe inherited blindness Leber congenital amaurosis (LCA). The similarity of AIPL1 to tetratricopeptide repeat (TPR) cochaperones that interact with the chaperone Hsp90 and the ability of AIPL1 to suppress the aggregation of NUB1 fragments in a chaperone-like man...

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Detalhes bibliográficos
Main Authors: Hidalgo-de-Quintana, Juan, Evans, R. Jane, Cheetham, Michael E., van der Spuy, Jacqueline
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2488389/
https://ncbi.nlm.nih.gov/pubmed/18408180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.07-1576
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